1647Are Hospital Floors an Underappreciated Reservoir for Transmission of Clostridium difficile and Methicillin-Resistant Staphylococcus aureus?

Recovery of MRSA and Clostridium difficile in an ICU ward

Introduction / objectives The role of the hospital environment as a reservoir of infection is poorly understood. Therefore, baseline levels of MRSA (methicillin-resistant Staphylococcus aureus) and Clostridium difficile contamination on surfaces were determined in an ICU ward. The aim was to determine whether contamination differs at certain times of the day, if recovery of pathogens is influen...

Hospital infection control strategies for vancomycin-resistant Enterococcus, methicillin-resistant Staphylococcus aureus and Clostridium difficile.

REVIEW ARTICLE Mechanisms for floor surfaces or environmental ground contamination to cause human infection: a systematic review

Shoe soles have been shown to transfer infectious microorganisms to floor and ground surfaces. However, the possible modes of transmission of infectious agents from floors or ground surfaces to human contact for infection have not been systematically reviewed. A systematic review was performed on articles indexed in medical databases (Medline, EMBASE, PubMed) using a pre-defined search strategy...

Ramoplanin at Bactericidal Concentrations Induces Bacterial Membrane Depolarization in Staphylococcus aureus

Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds to bacterial membranes as a C2 symmetrical dimer that can sequester Lipid II, ...

The Stealthy Superbug: the Role of Asymptomatic Enteric Carriage in Maintaining a Long-Term Hospital Outbreak of ST228 Methicillin-Resistant Staphylococcus aureus

UNLABELLED Whole-genome sequencing (WGS) of 228 isolates was used to elucidate the origin and dynamics of a long-term outbreak of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 228 (ST228) SCCmec I that involved 1,600 patients in a tertiary care hospital between 2008 and 2012. Combining of the sequence data with detailed metadata on patient admission and movement confirmed tha...